Death Receptor Signaling During E. Coli and Salmonella Infection

Grant number: 1044061 | Funding period: 2013 - 2015

Completed

Abstract

Upon encountering invading microorganisms, the body’s immune system usually initiates an inflammatory response to recruit populations of immune cells to the site of infection. To counter this attack, many bacterial pathogens have evolved distinct ways of disarming the inflammatory response. We are investigating the discovery that gastrointestinal bacteria such as Salmonella and pathogenic E. coli specifically interfere with the messages sent by the body’s innate sensors to recruit killer immune cells.

Related publications (8)

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

R Schuelein, H Spencer, LF Dagley, PF Li, L Luo, JL Stow, G Abraham, T Naderer, L Gomez-Valero, C Buchrieser, C Sugimoto, J Yamagishi, AI Webb, S Pasricha, EL Hartland

2018-09-01

The intracellular pathogen Legionella pneumophila influences numerous eukaryotic cellular processes through the Dot/Icm-dependent ..

Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli

GL Pollock, CVL Oates, C Giogha, TWF Lung, SY Ong, JS Pearson, EL Hartland

2017-04-01

During infection, enteropathogenic Escherichia coli (EPEC) translocates effector proteins directly into the cytosol of infected en..

Host Innate Immune Factors Influencing Enterohemorrhagic Escherichia coli Pathogenicity

Ying Zhang, Jaclyn S Pearson, Elizabeth L Hartland

2017-01-01

Enterohemorrhagic Escherichia coli (EHEC) is a significant foodborne attaching and effacing (A/E) pathogen that causes diarrhea, h..

Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli

T Wong Fok Lung, C Giogha, K Creuzburg, SY Ong, GL Pollock, Y Zhang, KY Fung, JS Pearson, EL Hartland

2016-05-01

Enteropathogenic Escherichia coli (EPEC) interferes with host cell signaling by injecting virulence effector proteins into enteroc..

Post-modern pathogens: Surprising activities of translocated effectors from E. coli and Legionella

JS Pearson, Y Zhang, HJ Newton, EL Hartland

2015-02-01

Many bacterial pathogens have the ability to manipulate cellular processes and interfere with host cell function through the trans..

The cell death response to enteropathogenic Escherichia coli infection

T Wong Fok Lung, JS Pearson, R Schuelein, EL Hartland

2014-12-01

Given the critical roles of inflammation and programmed cell death in fighting infection, it is not surprising that many bacterial..

A surprising sweetener from enteropathogenic Escherichia coli

JS Pearson, EL Hartland

2014-01-01

Infections with enteropathogenic Escherichia coli (EPEC) are remarkably devoid of gut inflammation and necrotic damage compared to..

Masters, marionettes and modulators: Intersection of pathogen virulence factors and mammalian death receptor signaling

J Silke, EL Hartland

2013-08-01

TNF and its receptor, TNFR1, are members of the TNF superfamily and play important roles during infection by orchestrating an infl..

University of Melbourne Researchers

Elizabeth Hartland